MUSCLE TWITCH TENSION: INFLUENCE OF ELECTRICAL STIMULATING CONDITIONS AT DIFFERENT TEMPERATURES. III. ANALYSIS AND CORRELATION,
Abstract:
Previous investigators have explained many of the effects induced by changes in both physical and chemical parameters on the amplitude of peak twitch tension as a direct consequence of changes in the duration of the active state. It is pointed out that recent experimental results indicate that the application of the active state concept to correlate earlier data on the variation of twitch tension with changes in temperature and chemical environment may now be open to question. A basis for correlating the data of a number of previous investigators on the amplitude of the single response of skeletal muscle under various conditions of stimulation with that of the present authors is presented. Arguments are formulated for the viewpoint that the acetylcholine coupling mechanism is not restricted to the endplate region. Author