STUDY OF THE PHYSIOLOGICAL CHEMICAL MECHANISMS OF THE TOXIC ACTION OF HYDRAZINES.

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Abstract:

The first four months of work have established procedures and also for the rat 1 provided symptomological evidence that hydrazine has a different mode of action from unsymmetrical dimethylhydrazine UDMH or monomethylhydrazine, 2 established LD50s with and without pyridoxine, 3 shown that UDMH and hydrazine stimulate respiration and inhibit glycolysis when brain slices from normal and poisoned rats are compared, 4 shown a profound e.g. 95 reduction in brain lactate by UDMH and hydrazine.

Author(s):
O'brien, R. D.
Author Organization(s):
CORNELL UNIV ITHACA N Y
Descriptive Note:
Quarterly rept. no. 2, 1 Oct-31 Dec 62,
Annotation:
Physiological chemical mechanisms of the toxic action of hydrazines on rats.
Pagination:
0011

Security Markings

DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Contract/Grant Number(s):
DA18 108CML7209
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*HYDRAZINES, *HYDRAZINE DERIVATIVES, TOXICITY, TOXICITY, CARBOHYDRATES, METABOLISM, BRAIN, BIOCHEMISTRY, RATS, POISONING, CONVULSIVE DISORDERS, VITAMIN B COMPLEX, GLYCOLYSIS, LACTATES, LETHAL DOSAGE
Keyword(s):
PYRIDOXAL 5 PHOSPHATE COENZYME, PYRIDOXAL
Report Date:
1963 Dec 31