ELECTROCHEMISTRY AND ELECTRON SPIN RESONANCE STUDIES OF THE PYRIDINE ALDOXIMES AND DERIVATIVES. I. POLAROGRAPHY OF THE PAM ISOMERS.

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Abstract:

The 2, 3, and 4 positional isomers of pyridine aldoxime and 1-methyl pyridinium aldoxime 1-PAM in dimethyl formamide were examined polarographically. Studies included the effects of concentration, water, acid, and base. Calculations were made of reduction-potential, diffusion-current constant, electrons transferred, shape, slope, and diffusion coefficient. Analysis of the electrochemical-reduction pathways suggested a number of one-electron changes and free-radical intermediates. The use of the electrochemical method of free-radical generation as an adjunct to electron spin-resonance spectroscopy was demonstrated in this study series. The use of the polarographic technique for qualitative and quantitative analyses was established. Electrochemical reduction of each of the above isomers proceeded in at least three steps. The 3 and 4 isomers appeared to have similar pathways, whereas the 2 isomers did not. Author

Author(s):
Giordano, Wally P. ; Mennitt, P. Gary
Author Organization(s):
CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD
Descriptive Note:
Technical rept. Oct 63-Apr 64,
Annotation:
Electrochemistry and electron spin resonance studies of the pyridine aldoximes and derivatives.
Pagination:
0050

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DOCUMENT & CONTEXTUAL SUMMARY

Distribution:
Approved For Public Release

RECORD

Collection: TR
Identifying Numbers
Report Number(s):
CRDLR-3316
Project Number(s):
DA-1C622401A097
 Subject Terms
Communities of Interest:
No COI(s) Identified
Descriptor(s):
*CHEMOTHERAPEUTIC AGENTS, *PYRIDINES, *OXIMES, MOLECULAR ISOMERISM, MOLECULAR STRUCTURE, ANTICONVULSANTS, THEORY, REDUCTION, TOXICITY, CHOLINESTERASE INHIBITORS, POLAROGRAPHIC ANALYSIS, ELECTRON PARAMAGNETIC RESONANCE, PH FACTOR, REACTION KINETICS, FREE RADICALS, REDUCTION(CHEMISTRY), CONCENTRATION(CHEMISTRY)
Field(s)/Group(s):
Pharmacology, Chemical, Biological and Radiological Warfare, Atomic and Molecular Physics and Spectroscopy
Keyword(s):
PYRIDINE ALDOXIMES
Report Date:
1965 Dec 01