ACUTE TOXICITY OF TETRAHYDROCANNABINOL TO MICE IN ALTERED ENVIRONMENTS

A dose range study and an acute intraperitoneal toxicity study were performed with tetrahydrocannabinol. The purpose was to determine whether any differences in physiological activity or acute intraperitoneal toxicity LD50 could be observed in mice housed at room temperatures of 70 degrees and 40 degrees F. Mice receiving tetrahydrocannabinol at a room temperature of 40 F exhibited the same physiological effects as mice receiving tetrahydrocannabinol at a room temperature of 70 degrees F. The acute intraperitoneal LD50 of tetrahydrocannabinol in mice at 70 F was 12537 mgkg. The acute intraperitoneal LD50 of tetrahydrocannabinol in mice at 40 F was 142mgkg. Tetrahydrocannabinol is nine times more toxic in mice subjected to the added stress of cold.