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Accession Number:
AD1208008
Title:
The Role of Key Paligenosis Gene IFRD1 in Gastric Carcinogenesis
Report Date:
2023-06-01
Abstract:
Gastric cancer is still one of the major threats to public health. Metaplasia is a well-known precursor to tumors although the molecular mechanisms that can link chronic inflammation, metaplasia and cancer are still vague. Paligenosis is a process by which chief cells in the stomach corpus can be recruited to become metaplastic and proliferate. IFRD1 is injury-induced protein that increases during paligenosis, the loss of which results in defective regeneration through p53 stabilization. We are seeking to determine if IFRD1 loss is associated with the prevalence of cancer and the mechanisms behind it. During the past year, I was able to determine that IFRD1 is a specific monosome-binding protein that can plug and salvage the ribosome from stress. I have published two papers, with another one under revision, and another two in draft. Furthermore, I presented a lecture at Digestive Disease Week 2022 and was invited for the talk at the Cincinnati Children's Hospital Medical Center to share my science.
Document Type:
Conference:
Journal:
Pages:
20
File Size:
0.57MB
W81XWH-22-1-0327
(W81XWH2210327);
Contracts:
Grants:
Distribution Statement:
Approved For Public Release
