Open tibia fractures are severe and common injuries sustained by Wounded Warriors in combat. Osteomyelitis and deep infection are unfortunately common after severe open fractures. Rates of infection following high-energy open fractures range from 6-40%. Furthermore, the injury mechanisms associated with the military involving penetrating fragments contribute to a higher rate of infection as compared to the civilian sector, in which blunt trauma is more common. To date, the field of orthopaedic surgery has not experienced a significant reduction in infection rates, despite numerous studies of a variety of different treatment options. Therefore, any novel strategy to reduce infection warrants rigorous study. The goal of this study is to investigate a potential treatment for serious open tibia fractures which are likely to become infected.