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Accession Number:
AD1195285
Title:
Delivery of Multifunctional Nanoparticles to the Brain
Report Date:
2022-03-04
Abstract:
Protein nanoparticles derived from non-enveloped viruses have several advantageous properties for the installation of new function. We used virus-like particles (VLPs) based on bacteriophage Q-beta, which means that the capsid structure has no natural and specific mammalian cell receptors. We therefore started with a structure that can interact with mammalian tissues only through nonspecific properties such as surface charge or hydrophobicity. While it can be difficult to eliminate such interactions, it is usually possible to do so, and specificity in binding and internalization can be separately introduced by the attachment of interacting groups on the particle surface.
Document Type:
Conference:
Journal:
Pages:
11
File Size:
2.64MB
W911NF-14-2-0091
(W911NF1420091);
Contracts:
Grants:
Distribution Statement:
Approved For Public Release
