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Transcription Factor Analysis of SLE
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease affecting predominantly young women during their peak productive years. Typical manifestations of SLE include a photosensitive rash, glomerulonephritis, arthritis, and serositis. In the USA, 1.5 million people are thought to be affected with annual direct care costs of $15,000 and annual lost productivity costs of $9,000 per patient. In addition, people with lupus can have compromised fertility and have a 30% rate of disability, demonstrating the profound impact of this disease. Mortality is thought to be about 2.5 fold higher than the general population with some demographic groups (children, women of color, those living in poverty) having a poorer prognosis. Premature vascular disease and depression represent significant chronic medical burdens.
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