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Heparin-Free Extracorporeal Life Support for Point-of-Need Treatment of Single and Multiorgan Failure
In this award we will develop and test a next generation ECLS system without systemic heparin administration using a combination of slippery surface blood repellent coating and impregnation of the ECLS circuitry with an extended-release nitric oxide (NO) formulation. A translational team composed of clinician scientists, chemists, respiratory therapists, and biomedical engineers at The Geneva Foundation, USAISR and the University of Georgia (UGA),will carry out a series of experiments. Rationale: the most severely injured combat casualties require new interventions which permit lung rest and recovery and support and stabilize vital functions during prolonged field care (PFC) and aeromedical evacuation. ECLS is lifesaving in the most severely injured in whom mechanical ventilation (MV) failed but requires systemic heparinization which is contraindicated in trauma. Objective/Hypothesis. Our research objective is to develop a new treatment for combat casualties with ARDS using ECLS without systemic heparinization. Hypothesis: Liquid-infused, nitric oxide releasing(LINOREL) coating permits heparin free ECLS in trauma while improving lung function, reducing minute ventilation and providing sustainable multiorgan support during PFC with aeromedical evacuation at altitude.
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