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Determination of Intranasal Deposition of Particles in Anatomically Correct Physical Models of Children and Adults and Comparison with Previous Studies
Physical models of the respiratory system provide a method for quantifying particle deposition in humans without exposing them to toxic agents. In this study, intranasal deposition of 0.5810 m particles of Arizona Test Dust was quantified in 3D printed models of 2-, 5-, and 18-year-old humans at flow rates representing sitting-awake, light-activity, light-exercise, and heavy-exercise conditions. Intranasal particle deposition was calculated as a function of impaction parameter. Results from this study were compared with previously published results in which liquid particles were used on age-matched humans and 3D models. Similar to findings from the previous studies, results from the present study showed that impaction is the predominant deposition mechanism for dry particles in intranasal airways. In addition, results for intranasal deposition in the present study showed agreement with results obtained in the previously published studies, which validates the use of these models to conduct deposition studies.
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