DID YOU KNOW? DTIC has over 3.5 million final reports on DoD funded research, development, test, and evaluation activities available to our registered users. Click HERE
to register or log in.
Age-Associated Microglia/Macrophage Response Inhibits Remyelination
Purpose: The purpose of this research is to evaluate whether reactive oxygen species are an age-associated inhibitor ofremyelination. We will evaluate ROS deposition during remyelination, evaluate the sources of ROS, and use ROS loweringmedications to evaluate how impacts remyelinationScope: We will use animal models of remyelination, microglial fate mapping, ROS measuring techniques and single cell RNAsequencing of ROS enriched cells to evaluate the source of ROS production. We will use medications to lower ROS andevaluate how ROS impacts remyelination
Approved For Public Release