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Accession Number:
AD1190606
Title:
Genomic Diversity and the Microenvironment as Drivers of Progression in DCIS
Report Date:
2020-10-01
Abstract:
Ductal carcinoma in situ (DCIS) of the breast is an increasingly common diagnosis that is related to aggressive screening patterns (mammography). This pre-invasive lesion may progress to invasive cancer, but does so at a relatively low frequency. Nonetheless, it is commonly treated with extensive surgery, radiation, and hormonal therapy even though most of these lesions would never progress to invasive cancer. Thus, there is a pressing clinical need to stratify the risk of DCIS tumors into those in need of intervention and those that can be safely monitored without intervention. Our project is designed to address this need by characterizing the evolvability of DCIS, detecting those that have a high likelihood of evolving to malignancy versus those that are likely to remain indolent.
Document Type:
Conference:
Journal:
Pages:
41
File Size:
5.56MB
W81XWH-14-1-0474
(W81XWH1410474);
Contracts:
Grants:
Distribution Statement:
Approved For Public Release
