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PSA Level During Midlife and Undiagnosed Prostate Cancer at Autopsy: Understanding Tumor Biology and Racial Disparities
Black men have a higher risk of prostate cancer diagnosis and death, but there remains a dearth of research investigations specifically focused on black populations and an inadequate evidence base for creation of screening guidelines for black men. Data from our group and others has shown that a single baseline PSA measured in midlife strongly predicts long-term risk of prostate cancer, particularly risk of aggressive disease, in both black and white men. We propose to further develop the evidence basis for a risk stratified baseline PSA screening strategy by conducting an autopsy study among black and white men to assess how PSA in midlife relates to the pre-diagnosis natural history of prostate cancer, and how this varies by race. This study is designed to explore the underlying biology by which midlife PSA predicts prostate cancer risk.
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