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Accession Number:

AD1168862

Title:

A Novel Approach for Identifying Individual Responses to Compromised Cerebral Oxygenation Challenges and Guided Intervention Using Compensatory Reserve Measurement

Author(s):

• Convertino, Victor A

Author Organization(s):

• BROOKE ARMY MEDICAL CENTER FORT SAM HOUSTON TX

Report Date:

2021-10-01

Abstract:

One of the primary challenges of effectively treating bleeding trauma patients is the difficulty with using relatively traditional vital signs to provide early and accurate detection for the onset of hemorrhagic shock. At present, an individual-specific, non-invasive method for early detection of patients at risk of progression to shock is a CDID gap requirement. The overall objectives of this research is to: (1) develop and validate a new algorithm that will provide early identification of hemorrhagic shock using real-time machine-learning technology for analysis of changes in features of non-invasive photoplethysmographic (PPG) waveforms specific to individual patients and clinical conditions (i.e., precision medicine); and (2) identify clinically useful genetic and epigenetic correlates of tolerance to blood loss as well as identify gene expression and metabolic changes that could reveal underlying molecular mechanism.

Document Type:

Conference:

Journal:

Pages:

74

File Size:

2.33MB

Contracts:

Grants:

Descriptors:

• health services
• medical personnel
• hemorrhagic shock
• burns
• cardiovascular physiological phenomena
• combat casualty care
• information science
• artificial intelligence
• machine learning
• birds
• cardiovascular surgery
• dermatologic agents
• hemorrhage
• personnel management
• statistical analysis
• accuracy
• data analysis

SubjectCategory:

• Biological and Medical Sciences

Communities of Interest:

• Autonomy

Distribution Statement:

Approved For Public Release

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