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Extracellular Vesicles as Potential Drivers of Myelin Health and Myelin Repair in Pregnant MS Patients
This research study explores whether Extracellular Vesicles (EVs) that are produced during pregnancy may have beneficial roles in Multiple Sclerosis, in particular, to myelin health and/or repair capacity. We have purified and characterized EVs from both pregnant and control mice, have performed pilot studies to determine the effect of pregnancy EVs on oligodendrocyte progenitor cell proliferation, differentiation, and myelin gene expression, and have begun our efforts to sequence miRNA cargos contained within pregnancy EVs.
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