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Accession Number:
AD1155887
Title:
The Role of Inflammation in Development of AD Following Repetitive Head Trauma
Report Date:
2020-08-01
Abstract:
Studies suggest that neuroinflammation-induced brain injury could be an initiating factor in developing Alzheimer's disease-related pathologies and provides substantial rationale to identify and characterize post-injury inflammatory biomarkers associated with repetitive brain trauma. To date, mechanisms linking TBI to AD remain unclear. Professional fighters experience repetitive brain injury that results in altered brain structures. We hypothesized that TBI-induced inflammatory response is critical in mediating AD-related pathology and specific inflammatory proteins can be used as post-injury biomarkers. The goal of the current study was to characterize inflammatory states in peripheral blood monocytes and plasma of active and retired MMA fighters and boxers from the Professional Fighters Brain Health Study. We examine 40 immune/inflammation-related biomarkers in the plasma of fighters and controls. We found changes specific to active fighters but some that persisted in retired fighters indicating some alterations persist chronically. Likewise, peripheral blood monocytes showed impaired TREM2 expression in both active and retired fighters, indicating that the deficiency is chronic.
Document Type:
Conference:
Journal:
Pages:
24
File Size:
1.84MB
W81XWH-15-1-0267
(W81XWH1510267);
Contracts:
Grants:
Distribution Statement:
Approved For Public Release
