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Identification of Mechanisms Underlying the Effects of Plasma Inclusive Resuscitation in Major Thermal Injury on Hemostasis and Vascular Homeostasis
Recently, investigation is re-emerging on optimizing burn shock resuscitation. Areas of interest include a variety of strategies for reducing volume requirements. Colloid is being trialed in attempts to improve the response to vascular leakage, intravascular volume expansion and reduction of volume. Off-the-shelf colloid options include fresh frozen plasma (FFP). Many prescribers of FFP report great response in regards to intravascular volume expansion with minimal side effects. Little is known about the impacts of these transfusion products on thermally-injured patients. We hypothesize that a PIR alters coagulation homeostasis in a positive manner while combating the effects vascular endothelial dysfunction and modulating the inflammatory host response. This prospective, systematic, and comprehensive characterization of FFP and its impacts on hemostatic and inflammatory potential of burn patients will be broadly applicable because it will serve to advance the body of knowledge available on blood products.
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