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Accession Number:
AD1155723
Title:
T Cells and Rejection in Vascularized Composite Allotransplants
Report Date:
2022-01-01
Abstract:
Immune rejection is a major barrier to wider implementation of vascular composite allografts (VCAs) that hold great promise for restoring function in American service members, who have suffered devastating traumatic injuries. Despite systemic immunosuppression, T cell mediated rejection (TCMR) occurs much more frequently in VCA than in solid organ transplants, likely due to the significant number of donor T cells that survive in the allografts. This study will use banked tissues from VCA patients to comprehensively analyze the contributions of donor versus recipient T cells in VCA rejection. Another question that will be addressed is whether sentinel flaps, transplanted concomitantly with the allograft from the same donor to a distant anatomical site, or circulating levels of clonally expanded T cells, are useful as reliable markers for VCA rejection. IRB and HRPO approval for this project has been obtained.
Document Type:
Conference:
Journal:
Pages:
9
File Size:
0.27MB
W81XWH-18-1-0785
(W81XWH1810785);
Contracts:
Grants:
Distribution Statement:
Approved For Public Release
