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Gender Differences in Complement-Mediated Reperfusion Injury
With increased female soldiers being exposed to combat, the number of women wounded or injured also increases. However, the rate of female combat deaths and extremity or abdominal injuries is significantly higher than within the male population. Thus, understanding mechanistic and treatment differences between men and women is critical. The mechanisms of excessive inflammation in intestinal ischemia/reperfusion injury includes complement activation and neutrophil infiltration in male mice. Due to females experiencing different symptoms, we hypothesized that the mechanisms of inflammation would differ. Our current data demonstrate that female mice use different complement initiators and regulators resulting in distinct kinetics of complement activation as well as inflammatory cell infiltration. Together, these data suggest that sex specific treatments may be required for ischemic events.
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