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Vitamin D Deficiency Leads to Increased Intraprostatic Hormones in African American Men
Our most significant finding for Y2 of this project is the profound defect in prostate differentiation observed in the organoids lacking Megalin, which supports its role in hormone import. We have also focused in HSD17B7 as a key gene differentially expressed by African Ancestry. HSD17B7 is a key enzyme for estrogen metabolism and we found that it is higher in AA prostate stroma on a TMA. Further, HSD17B7 expression is increased by estrogen and androgen in patient-derived stromal cells, validating the microarray data.
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