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Accession Number:
AD1155385
Title:
Precision Oncology-Based Therapeutic Targeting in Mesothelioma
Report Date:
2021-09-01
Abstract:
Given that mesothelioma nearly universally exhibits cell cycle abnormalities and the cell cycle interacts with multiple pathways important to the growth of mesothelioma, disruption of the cell cycle presents as a likely effective approach (or will contribute to a multiple pathway-targeted combination approach) to treating mesothelioma clinically. Our hypothesis is that combined inhibition of 1) multiple cell cycle proteins, and 2) one of 3 separate and alternative molecular pathways will serve as an effective therapy against multiple molecular subtypes of mesothelioma. Scope: We are utilizing in vitro and in vivo studies to evaluate how to best target molecular subtypes of mesothelioma. Major Findings: We have determined in multiple cell lines that cell cycle inhibitors(dinaciclib, abemaciclib, palbociclib) and inhibitors of antioxidant defense (gentian violet and auranofin) have significant activity against mesothelioma in vitro.
Document Type:
Conference:
Journal:
Pages:
20
File Size:
1.46MB
W81XWH-19-1-0612
(W81XWH1910612);
Contracts:
Grants:
Distribution Statement:
Approved For Public Release
