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Accession Number:

AD1151217

Title:

The Impact of Germline Predisposition to Myelodysplastic Syndrome on Allogeneic Hematopoietic Stem Cell Transplant Outcomes Using Related Donors

Author(s):

• Godley, Lucy A.

Author Organization(s):

• CHICAGO UNIV IL

Report Date:

2021-08-01

Abstract:

We will use samples from the Center for International Blood and Marrow Transplant Research (CIBMTR) to determine the frequency with which germline mutations occur in myelodysplastic syndrome (MDS) patients across the entire age spectrum. In addition to determining mutation frequency, we will associate the germline status of both matched-donor and recipient with engraftment kinetics and post-transplant outcomes. This comprehensive study will change the diagnostic and hematopoietic stem cell transplantation (HSCT) planning work-up for MDS patients by identifying age groups that are most likely to have a germline predisposition mutation, which will position the HSCT field to implement appropriate clinical testing strategies across the world to detect these types of mutations in MDS patients. This work will also shape HSCT policies regarding allogeneic stem cell donor choices and transplantation protocols for these patients with the goal of improving outcomes.

Document Type:

Conference:

Journal:

Pages:

13

File Size:

0.63MB

Contracts:

Grants:

Descriptors:

• stem cells
• transplants
• hematologic diseases
• age groups
• cells
• medical personnel
• abstracts
• biomedical research
• mutations
• professional development
• transplantation
• data analysis
• frequency
• diseases and disorders
• local governments
• patent applications
• statistical analysis

Identifiers:

• Germline predisposition
• myelodysplastic syndrome
• hsct(hematopoietic stem cell transplantation)

SubjectCategory:

• Biological and Medical Sciences

Communities of Interest:

• Biomedical

Distribution Statement:

Approved For Public Release

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