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Accession Number:
AD1135354
Title:
Integration and Recellularization of Microparticles for the Repair of Tissue Defects
Report Date:
2021-05-01
Abstract:
Our proposal advances the use of reconstituted decellularized and particulated articular cartilage, termed cartilage clay, as a new tissue repair technology following trauma. Osteoarthritis is a debilitating disease that afflicts nearly 20% of people in the United States and is extremely common among military personnel. In an effort to understand and improve integrative cartilage repair for the treatment of osteoarthritis, we have pioneered tissue engineering technology that utilizes decellularized cartilage microparticles packed in a hydrogel. We are studying the extent that cartilage clay will 1) encourage a regenerative response in damaged tissue regions, 2) mimic the structural support of native tissue, 3) establish an environment that promotes attachment, migration, and differentiation of infiltrating cells, and 4) provide an inductive ECM and source of growth factors and other anti-catabolic growth factors and cytokines. We will optimize the cartilage clay design and establish preclinical efficacy of a new, easy-to-apply cartilage repair strategy that facilitates efficient host cell response in vivo.
Document Type:
Conference:
Journal:
Pages:
10
File Size:
0.31MB
W81XWH-20-1-0268
(W81XWH2010268);
Contracts:
Grants:
Distribution Statement:
Approved For Public Release
