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Accession Number:
AD1122935
Title:
Multi-Omics and Mitochondrial Dysfunction in Acute Lung Injury
Report Date:
2020-10-01
Abstract:
Traumatic injury is a leading cause of respiratory failure, where 2-4 of persons with trauma develop acute lung injury/ acute respiratory distress syndrome (ALI/ARDS). Septic shock with acute organ dysfunction is a common complication of severe trauma, with 40 of estimated mortality rates. A key feature in trauma-associated ALI/ARDS and sepsis is the impairment of pulmonary vascular integrity. During sepsis, ALI/ARDS results from activation of innate immune cells and endothelial cells by endotoxins leading to systemic inflammation and oxidative stress, which results in endothelial cell death and loss of integrity of the pulmonary vascular endothelium. However, the mechanisms leading to ALI/ARDS remains elusive.
Document Type:
Conference:
Journal:
Pages:
11
File Size:
0.28MB
W81XWH-19-1-0659
(W81XWH1910659);
Contracts:
Grants:
Distribution Statement:
Approved For Public Release
