Traumatic injury is a leading cause of respiratory failure, where 2-4 of persons with trauma develop acute lung injury/ acute respiratory distress syndrome (ALI/ARDS). Septic shock with acute organ dysfunction is a common complication of severe trauma, with 40 of estimated mortality rates. A key feature in trauma-associated ALI/ARDS and sepsis is the impairment of pulmonary vascular integrity. During sepsis, ALI/ARDS results from activation of innate immune cells and endothelial cells by endotoxins leading to systemic inflammation and oxidative stress, which results in endothelial cell death and loss of integrity of the pulmonary vascular endothelium. However, the mechanisms leading to ALI/ARDS remains elusive.