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Accession Number:

AD1122456

Title:

Examination of Neuroimaging, Cognitive Functioning, and Plasma Markers in a Longitudinal Cohort of Gulf War Deployed Veterans: The Fort Devens Cohort

Author(s):

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Report Date:

2020-10-01

Abstract:

This study aims to conduct follow-up longitudinal cognitive evaluations on a sub-sample of 100 Time 3 Ft. Devens Cohort veterans, most of whom were last evaluated in-person for cognitive functioning and with neuroimaging in the mid-1990s, to compare objective measurement of reported decline; and to determine cross-sectional blood and neuroimaging biomarkers (blood and structural volumetrics will also include longitudinal analyses) at 25 plus years post deployment to the Gulf region, that may be consistent with cognitive outcomes and presumed pathobiological mechanisms (oxidative stress, ROS) of GWI. These data will evaluate the utility of previously unavailable blood and neuroimaging markers of oxidative stress, to devise a new diagnostic test for GWI in subgroups of GW veterans(TBI and OP exposed), and to provide a potential objective biomarker of treatment efficacy in clinical trials.

Pages:

35

File Size:

1.99MB

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Distribution Statement:

Approved For Public Release

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