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Accession Number:
AD1122444
Title:
Targeting Histone Deacetylase in Focal Segmental Glomerulosclerosis-From Mice to Patients
Report Date:
2020-10-01
Abstract:
Glomerular diseases account for approximately 80 of end stage kidney disease (ESKD). Nearly 600,000 USresidents have end-stage kidney disease (ESKD) at an annual Medicare expenditure of 28 billion dollars. ThroughRNA profiling in our models of FSGS, we have found that HDAC activity is increased in the glomerulus andblocking with HDAC inhibitor, valproic acid or suberanilohydroxamic acid mitigates progression of kidney disease.During the last funding period, we have generated podocyte specific knockout mice for HDAC1 and 2, which alsoappears protective against glomerular injury in toxin mediated and genetic mouse models. In parallel, the co-PI ofthis study, F. Perry Wilson has continued to examine the Veterans Affairs Cohort and added multiple other cohortsto examine the stability of preliminary results that suggested a protective role of VPA in proteinuric kidney disease.
Document Type:
Conference:
Journal:
Pages:
14
File Size:
0.89MB
W81XWH-17-1-0663
(W81XWH1710663);
Contracts:
Grants:
Distribution Statement:
Approved For Public Release
