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Accession Number:
AD1112107
Title:
Sub-Diffraction Temperature Mapping of Protein Interconversions
Report Date:
2020-09-15
Abstract:
The ability to spatially and temporally map nanoscale environments would be highly transformative for revealing dynamic biophysical phenomena. As investigations of time-dependent processes demand broad time observation windows previously unreachable by fluorescence super-resolution, a nonbleaching strategy is needed. We developed precision optics to suppress errors required for subdiffraction imaging. We scaled this method to unlimited numbers of scatterers. With a nonbleaching subdiffraction approach capable of broad timescales, we followed the temporal evolution of actin materials with subdiffraction resolution over broad time periods.
Document Type:
Conference:
Journal:
Pages:
15
File Size:
1.74MB
FA9550-16-1-0272
(FA95501610272);
Contracts:
Grants:
Distribution Statement:
Approved For Public Release
