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Accession Number:

AD1096483

Title:

Development of Smoothened Agonist Non Phospholipid Liposomal Nanoparticles for Bone Repair

Author(s):

• James, Aaron W.

Author Organization(s):

• Johns Hopkins University

Report Date:

2019-08-01

Abstract:

Non-healing bone defects remain a significant problem for combat casualties and military veterans. A principle challenge is to develop therapeutic agents that safely and effectively improve growth and differentiation factor (GDF) based skeletal regeneration. The manipulation of Hedgehog signaling is a promising alternative to BMP2 for improved bone repair outcomes. Recently, we observed thatthe small molecule Hedgehog agonist SAG demonstrates pro-osteogenic / pro-vasculogenic effects to induce mouse calvarial defect healing. Independently, we have developed innately osteoinductive Stearylamine and Oxysterol (SA/Oxy) nanoparticles (NPs), and showed their high drug loading efficiency and synergistic osteoinductive potential with the small molecule SAG. In the current proposal, we willcombine these recent breakthroughs to develop a next generation NP packaged small molecule as a bone graft substitute product to jumpstart endogenous bone repair.

Document Type:

Conference:

Journal:

Pages:

22

File Size:

1.63MB

Contracts:

Grants:

Descriptors:

• medical personnel
• osteogenesis
• membrane lipids
• peptide growth factors
• bone and bones
• bone regeneration
• nanomaterials
• nanoparticles
• department of defense
• molecules
• nanotechnology
• stem cells
• therapy
• cells (biology)
• chemistry
• coatings
• materials
• x ray photoelectron spectroscopy
• biomedical research
• bone marrow

Identifiers:

• Bone repair
• bone regeneration
• bone tissue engineering
• Hedgehog signaling
• Smoothened
• Oxysterol

SubjectCategory:

• Biological and Medical Sciences

Distribution Statement:

Approved For Public Release

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