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Accession Number:
AD1093791
Title:
Optimizing Skin-Implant Interface of Osseointegrated Device
Report Date:
2018-10-01
Abstract:
This study focuses on an OI prosthetic implant anchored in the long bone of a residual limb and exiting through the skin. Implant and soft-tissue infections and implant loosening are common complications for both upper and lower extremity bone-anchored implants, resulting in revision surgeries and increased morbidity. We explore the possibility of creating a tight, durable skin-implant interface for OI implants using mesenchymal stem cells (MSCs) derived from naturally occurring porcine integumentary tissues or human induced pluripotent stem (iPS) cells, which have the intrinsic potential to form an impervious seal at hard and soft tissue junctions. Initial porcine cell characterization is ongoing.
Document Type:
Conference:
Journal:
Pages:
19
File Size:
0.58MB
W81XWH-17-2-0059
(W81XWH1720059);
Contracts:
Grants:
Distribution Statement:
Approved For Public Release
