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Accession Number:

AD1093593

Title:

MicroRNA in Prostate Cancer Racial Disparities and Aggressiveness

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Report Date:

2018-12-01

Abstract:

We examined the association of plasma miRNA levels and inherited polymorphisms in genes in the microRNA (miRNA) biogenesis pathway with prostate cancer aggressiveness among African American (AA) and European American (EA) men with prostate cancer (PCa) from the Karmanos Cancer Institute in Detroit, MI. We demonstrated that a previously unreported circulating miRNA signature consisting of two distinct combinations of miRNAs (miR-17/miR-192) and (miR-146a/miR-20a/miR26b) is capable of segregating aggressive and non-aggressive prostate cancer in both AA and EA patients. When we evaluated SNPs in genes involved in the miRNA biogenesis pathway, multiple SNPs in TARBP1, DROSHA and DICER1 were significantly associated with PCa aggressiveness in AA men. Fewer SNPs were significantly associated with PCa aggressiveness in EA men, and were primarily located in TARBP1 and DROSHA. Only 1 SNP was significant for both the AA and EA adjusted analyses: rs4920247, which is an intronic SNP located in TARBP1.

Pages:

37

File Size:

1.58MB

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Distribution Statement:

Approved For Public Release

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