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Alginate Oligomers to Treat Infectious Microbial Biofilms


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War burn wounds become colonized with pathogenic microorganisms including Acinetobacter (ACETB) and Pseudomonas (PSEUD) leading to formation of biofilms. The following two hypotheses have been proposed to test the efficacy of AlgiPharmas alginate oligomer (Oligo G) in disrupting biofilms for treatment of microbial infections as well as an adjuvant effect for other therapies such as antibiotic treatment. Hypothesis-1 Biofilm is formed on pre-clinical full-thickness porcine burn wounds and impairs healing. Hypothesis-2. OligoG inhibits biofilm formation and potentiates antibiotic activity against gram negative infected wounds. As per timeline, the studies (4 sub aims) proposed to test Hypothesis-1 have concluded in year1.We have successfully Developed and characterized the first reproducible pre-clinical large animal (porcine) model of biofilm infection in burn injuries. We show that biofilm infections increase inflammation and impair healing of burn wounds. This model is likely to facilitate the early development and testing of novel (and existing) treatment interventions with proposed anti-bacterial or anti-biofilm therapies in skin injuries. Development of such model is critical in the translation of this program to clinical practice. The next step will be to take the findings of the proposed study to clinical testing of OligoG.



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