The objective of this study was to use finite element simulations to design new underbody armor truss structures for buried blast mitigation. A selected, small-scale structure was fabricated using additively manufactured Ti-6Al-4V and subjected to an equivalently small-scale buried blast test. Boundary conditions generated by the Moment Impulse Numerical Evaluation (MINE) code suite were applied within LS-DYNA and used to analyze the structural response of the candidate truss structure subjected to buried blast loading. Simulation results were compared to data from the experimentally fabricated and tested structure, giving close agreement between measured and predicted behavior. Overall, the chosen structure was shown to reduce the peak deflection by 55 percent when compared with the performance of a flat, monolithic Ti-6Al-4V plate of equivalent areal density.