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Accession Number:

AD1089962

Title:

A Precision Medicine Study of How Inflammation May Underlie the Excessive Burden of Prostate Cancer in Men of African Ancestry

Author(s):

• Ambs, Stefan

Author Organization(s):

• The Geneva Foundation

Report Date:

2019-10-01

Abstract:

Men of African descent experience a disproportionately high prostate cancer mortality. We and others have shown that prostate tumors in African-Americans harbor a distinct immuneinflammation signature. Low-grade inflammation has been described as a prostate cancer risk factor that is associated with aggressive disease. We also reported that regular aspirin use reduces the risk of aggressive prostate cancer and disease recurrence in these men. Together, the observations suggest that a low-grade chronic inflammation related to ancestral factors and tumor biology could be a driver of prostate cancer mortality in men with African ancestry.

Document Type:

Conference:

Journal:

Pages:

14

File Size:

0.97MB

Contracts:

Grants:

Descriptors:

• medical personnel
• african americans
• diseases and disorders
• inflammation
• neoplasms
• risk factors
• data acquisition
• data analysis
• prostate cancer
• fatty acids
• personalized medicine
• pilot studies
• acquisition
• data science
• department of defense
• mass spectrometry
• measurement
• observation
• tissues
• laboratory procedures

Identifiers:

• Low-grade inflammation
• aggressive disease
• regular aspirin
• aggressive prostate cancer
• low-grade chronic inflammation
• ancestral factors
• tumor biology

SubjectCategory:

• Biological and Medical Sciences

Distribution Statement:

Approved For Public Release

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