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Accession Number:

AD1064887

Title:

Identification of Epigenetic Signatures as Biomarkers of Gulf War Illness

Author(s):

• Malanoski, Anthony P.
• Leski, Tomasz

Author Organization(s):

• Naval Research Laboratory

Report Date:

2018-10-01

Abstract:

The objective of this research proposal is to use integrated approaches to investigate epigenetics changes of GWI and correlate the epigenetic changes with GW-relevant exposures(PB, pesticides, sarin) to identify the biological indicators in GWI pathogenesis in a well-established cohort of Gulf War veterans from the large multi-site DOD-funded Boston Gulf War Illness Consortium (GWIC) (GW120037). The most significant accomplishments in the initial year was developing protocols and obtaining approval of human subject research plans so that samples could be received. A meeting with contributors from the University of Boston occurred to finalize experimental plans. Supplies and equipment were ordered to facilitate experimental plan.

Document Type:

Conference:

Journal:

Pages:

6

File Size:

0.29MB

Contracts:

Grants:

Descriptors:

• persian gulf syndrome
• consortiums
• contracts
• department of defense
• epigenetics
• high performance computing
• pathogenesis
• public health
• universities
• computational biology
• indicators
• military research
• pesticides
• biological markers
• biomedical research
• identification
• navigational equipment
• patent applications
• biological sciences
• biology

Identifiers:

• gwi(Gulf War Illness)
• DNA Methylation
• microRNAs
• bioinformatics

SubjectCategory:

• Biological and Medical Sciences

Distribution Statement:

Approved For Public Release

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