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Accession Number:

AD1049907

Title:

Branched Nerve Allografts to Improve Outcomes in Facial Composite Tissue Transplantation

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Author Organization(s):

Report Date:

2017-12-01

Abstract:

The gold standard for peripheral nerve gap repair remains the autologous nerve graft. However, off-the-shelf alternatives are appealing due to additional graft material, shorter operative times and avoidance of donor site morbidity. This study aims to evaluate the functional and histologic recovery of a novel branched a cellular nerve allograft (ANA) in a complex nerve defect. Yucatan miniature swine (n = 13) underwent transection of the left inferior division of the facial nerve containing the marginal mandibular (MMB) and cervical (C) nerve branches. The gap was addressed either by a sural nerve autograft, ANA, or a human xenograft with or without oral Tacrolimus. Electrophysiologic assessments were performed pre-operatively and at the study endpoint (24 weeks) to assess functional recovery using compound muscle action potential (CMAP) and histologic recovery by immunohistochemistry (IHC) using neurofilament and S100.

Pages:

35

File Size:

4.62MB

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Distribution Statement:

Approved For Public Release

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