View The Document

Accession Number:

AD1046165

Title:

Improving Ischemia Reperfusion Injury in Vascularized Composite Tissue Allotransplantation Via Histone Deacetylase Modulation

Author(s):

• Levine, Matthew H.

Author Organization(s):

• Trustees of the University of Pennsylvania

Report Date:

2017-10-01

Abstract:

This work proposes to investigate the impact of histone deacetylase (HDAC) drug inhibition or deletion on the tolerance of limb warm and cold ischemia reperfusion injury (IRI) in scenarios relevant to limb transplantation using mouse models for experimentation. Limitations in tolerated ischemia times limits the scope of donors that can be considered for any particular vascularized composite allotransplant (VCA) recipient. Mitigating IRI therapeutically would have significant impact on the applicability of VCA to military personnel suffering catastrophic limb or tissue loss.

Document Type:

Conference:

Journal:

Pages:

17

File Size:

1.66MB

Contracts:

Grants:

Descriptors:

Identifiers:

• vca(Vascularized composite allotransplantation)
• hdac(Histone deactylase)
• iri(ischemia reperfusion injury)
• cold ischemia
• warm ischemia
• mouse
• limb transplantation

SubjectCategory:

• Biological and Medical Sciences

Distribution Statement:

Approved For Public Release

View The Document