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Accession Number:

AD1043038

Title:

Acute and Two-Week Inhalation Toxicity Studies in Rats for Polyalphaolefin (PAO) Fluid

Author(s):

• Mattie, David R.
• Wegner, Matthew D.
• Wong, Brian A.
• James, R. A.
• Mumy, Karen L.
• McInturf, Shawn M.
• Marcel, Barry J.
• Sterner, Teresa R.

Author Organization(s):

• HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE

Report Date:

2017-04-01

Abstract:

Formal occupational exposure limits (OELs) for polyalphaolefin (PAO) fluids have not been proposed. Specific PAO fluids are used as aircraft hydraulic fluid components or heat sink coolants for aircraft service air and electronics. Studies compared toxicity of a PAO fluid in male and female Fischer 344 rats by acute inhalation (0, 100, 500 and 1000 mg/m3 aerosol for 6 hours) and two-week inhalation (0, 20, 100 and 300 mg/m3 aerosol for 6 hours/day, five days/week for two weeks). Neurobehavioral tests following the acute exposure showed that both sexes were passive after exposure to 1000 mg/m3 PAO, and to a lesser extent after 500 mg/m3 PAO. Body weight, food and water consumption were also affected, with recovery after 24 hours.

Document Type:

Conference:

Journal:

Pages:

252

File Size:

5.81MB

Contracts:

Grants:

Descriptors:

• medical personnel
• body weight
• air force
• animal structures
• chemistry
• granulocytes
• measurement
• particle size
• statistical tests
• air flow
• heat sinks
• hemorrhage
• nose
• particles
• static pressure
• statistical analysis
• air force operations
• aircrafts
• chi square test
• human behavior

Identifiers:

• inhalation
• neurotoxicology
• PAO(polyalphaolefin)
• OELS(EXPOSURE LIMITS)

SubjectCategory:

• Biological and Medical Sciences

Communities of Interest:

• Biomedical

Distribution Statement:

Approved For Public Release

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