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Accession Number:
AD1013932
Title:
Magnesium Sulfate and Betamethasone Reduce NUR77 Expression in a Preterm Labor Mouse Model
Report Date:
2016-06-29
Abstract:
Women in pretem1 labor are commonly treated with magnesium sulfate (MgS04) and betamethasone (BMTZ) to reduce complications of prematurity including neurologic injury. MgS04, however, prevents cerebral palsy in only I in 40 women who receive it. Understanding the cellular responses to MgS04/BMTZ could allow for more effective treatments. Nur77 is a nuclear receptor implicated in apoptosis and immune responses- processes that occur in neuroinflammation. Our objective was to investigate if Nu r77 is increased in the setting of inflammation-induced pretem1 labor and to determine the impact ofMgS04 and BMTZ treatments. Methods: Using an established mouse model, we induced inflammation in pregnant mice using lipopolysaccharide (LPS) then randomized them for treatment with MgS04 and/or BMTZ or saline. Treatment with MgS04 and BMTZ in our model significantly reduced Nur77 expression. This finding suggests one mechanism by which these medications prevent neurologic injury in the pretem1 infant.
Document Type:
Conference:
Journal:
Pages:
11
File Size:
1.96MB
Contracts:
Grants:
Distribution Statement:
Approved For Public Release
