Accession Number:

ADB155800

Title:

Systematic Mustard Gas Scavengers

Personal Author(s):

Corporate Author:

SRI INTERNATIONAL MENLO PARK CA

Report Date:

1991-04-17

Abstract:

The synthesis methodology for preparing four types of novel nucleophilic scavengers for experimental treatment of HD intoxication is described. The four types include 3-alkoxyquinuclidines, 4-dialkyl aminopyridines, N-alkylpyridine-4-thiones, and imidazoline-2-thiones. A total of 4 compounds representing three of the classes were prepared, characterized, and submitted to WRAIR for biological evaluation. In addition, a convenient kinetic screen to rank target compounds in order of relative reactivity was established.

Descriptive Note:

Midterm progress rept. 5 Mar 1990-4 Mar 1991

Supplementary Note:

DOI: 10.21236/ADB155800

Pages:

0028

Modernization Areas:

Distribution Statement:

Approved for public release; distribution is unlimited.

Contract Number:

DAMD17-90-C-0034

File Size:

2.40MB