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Accession Number:
ADB124358
Title:
Synthesis of Nucleoside Mono- and Dialdehydes as Antiviral Agents
Corporate Author:
ROCHESTER INST OF TECH NY
Report Date:
1987-12-15
Abstract:
Two compounds, 4, 5-unsaturated adenosine-2, 3-dialdehyde and tubercidin-2, 3-dialdehyde were submitted during the reporting period. Work on the synthesis of adenosine-2-monoaldehyde, adenosine-3-monoaldehyde and 5deoxyadenosine-2, 3-dialdehyde is still in progress. As a group the nucleoside dialdehydes thus far submitted have shown broad spectrum activity against many of the viruses in the screening system, and some, like guanosine dialdehyde, have shown remarkably low cytotoxicity. Even dialdehydes that cannot become phosphorylated, which is required for the antiviral activity of all clinically used nucleoside antivirals, showed antiviral activity. For example 5-fluoro-5-deoxyadenosine-2, 3-dialdehyde showed good activity against yellow fever and 4, 5-unsaturated adenosine-2, 3-dialdehyde showed excellent activity against vesicular stomatitis virus. Keywords Antiviral agents.
Descriptive Note:
Annual rept. 15 Nov 1986-14 Nov 1987
Supplementary Note:
DOI: 10.21236/ADB124358
Pages:
0024
Contract Number:
DAMD17-86-C-6002
File Size:
1.19MB
