Validation of a Protocol to Compare the Effectiveness of Experimental Decontaminants with Both Components of the M258A1 Kit Against Percutaneous Application of Undiluted Vesicant Chemical Surety Materiel to the Laboratory Albino Rabbit.
A rabbit model was developed and validated for screening noninvasive candidate decontamination systems for their efficacies against topical exposure to the vesicant chemical surety material sulfur mustard HD. Rabbits were dosed with HD on their shaved dorsa and then decontaminated at varying times with either both components of the M258A1 field kit or twice with distilled water. Lesion lengths were estimated and compared contralaterally. Results revealed statistically shorter lesions for M258A1 decontamination relative to the respective lesions decontaminated with distilled water.