Accession Number:

ADA278652

Title:

Malaria Vaccine Study Site in Irian Jaya, Indonesia: Plasmodium Falciparum Incidence Measurements and Epidemiologic Considerations in Sample Size Estimation

Personal Author(s):

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Report Date:

1994-01-01

Abstract:

Malaria epidemiologic and entomologic studies were performed during both the high transmission and low transmission seasons to characterize the Plasmodium falciparum malaria transmission at a proposed malaria vaccine trial size in Irian Jaya, Indonesia. The study population consisted of two subsets native Irianese men with lifelong exposure to malaria and transmigrants who arrived from a nonmalarious area 2.5 years before the start of the study. All subjects received a radical cure for malaria and were then monitored weekly by blood film. Both P. falciparum malaria attack rates and incidence densities were calculated transmigrants had a significantly higher rate P0.003 than the Irianese during the low transmission season study 20 weeks long but not during the high transmission season study 12-weeks long. Lack of exposure-induced immunity left the transmigrants at a minimum 17-25 greater relative risk of becoming parasitemic compared with the Irianese during the low transmission season study.

Descriptive Note:

Journal article

Pages:

0007

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Identifiers:

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Distribution Statement:

Approved for public release; distribution is unlimited. Document partially illegible.

File Size:

0.56MB

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