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Accession Number:
ADA278229
Title:
Staphylococcal Enterotoxin: Role of Intestinal Immunity in Enterotoxin B Intoxication
Corporate Author:
DEFENCE RESEARCH ESTABLISHMENT SUFFIELDRALSTON (ALBERTA)
Report Date:
1994-02-01
Abstract:
To investigate the role of intestinal immunity in staphylococcal enterotoxins intoxication. We have chosen the mouse as experimental model, which although resistant to enterotoxins, has a certain advantage by not having an emetic mechanism, thus no loss in peroral administered enterotoxin takes place. Parenteral administration of enterotoxins induced a high titer of specific antibodies in serum, mainly of IgG and IgG2a subclasses. Peroral administration of enterotoxin elicited a good response at the intestinal level as showed by specific anti-enterotoxin antibodies in the supernatants of in vitro cultured intestinal fragments and the synthesized immunoglobulin was IgA. When different routes and combinations of them were studied it was observed that a parenteral followed by peroral administration of enterotoxin induced the higher intestinal immune response. Secretion of specific anti-enterotoxin antibodies by intestinal immune system also lasted longer compared to the presence of antibodies in serum of perorally by immunized animals. Staphylococcus aureus, Enterotoxin B, IgA, Immunity.
Descriptive Note:
Memorandum rept.
Pages:
0025
Distribution Statement:
Approved for public release; distribution is unlimited.
File Size:
0.95MB
