The research proposed under this contract is a feasibility study in the development of applications of new microcomputer graphics technology to the analysis and interpretation of clinical pharmacological data. This involves continuing development of comprehensive programs for analysis, interpretation, and simulation of pharmacokinetic data, dose-response kinetic data, and other data relevant to new drug development, for use with the Tektronix 4052 Microcomputer Graphics System. The combination of such modern analytical and illustrative methods in clinical pharmacology, based on new high-speed microcomputers and associated graphics, are thought to greatly reduce both cost and time involved in the overall process of clinical evaluation of new drugs in the U.S. Army Development Program. The work performed includes the following Continuing development of a non-linear pharmacokinetic data fitting program to analyze drug data where non-linear processes are responsible for some of the drug disposition pathways. Development of a pharmacokinetic and pharmacodynamic data simulation program to simulate both time courses of drug concentrations and pharmacologic effect. Keywords Clinical pharmacokinetics, Dose-response relations, Pharmacokinetic simulation, Non-parametric statistics, Mefloquine, Microcomputer graphics, Tektronix 4052.