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Accession Number:
ADA056351
Title:
The Application of Robust Calibration to Radioimmunoassay.
Corporate Author:
STATE UNIV OF NEW YORK AT BUFFALO AMHERST STATISTICAL SCIENCE DIV
Report Date:
1977-06-01
Abstract:
In this paper, a new approach to the analysis of RIA data is discussed. An algorithm is presented for obtaining the M-estimates of nonlinear calibration curves. The curves to be fitted are modified hyperbolae based on 12 to 16 observations. A procedure, based on the application of the Bonferroni Inequality, is presented for obtaining tolerance-like interval estimates of the concentration of the hormone of interest in the patients. Results of simulations are cited to support the method of construction of confidence bands for the fitted calibration curve. Data obtained from the Veterans Hospital, Buffalo, New York are used for examples throughout the paper. Author
Descriptive Note:
Technical rept.,
Pages:
0036
Contract Number:
N00014-75-C-0734
File Size:
10.47MB
