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Accession Number:
AD1112011
Title:
Differential Effects of Modafinil on Performance of Fatigue Susceptible and Fatigue Resistant Individuals
Corporate Author:
NAVAL MEDICAL RESEARCH UNIT (DAYTON) WRIGHT-PATTERSON AFB OH WRIGHT-PATTERSON AFB
Report Date:
2020-10-01
Abstract:
Sleep deprivation uniquely affects individuals, with some displaying more resistant tendencies than others, demonstrating the need for countermeasures for fatigue-vulnerable individuals. The present study examined whether 200mg modafinil affects the performance of fatigue-vulnerable differently than fatigue-resistant individuals. Using a 3-way, placebo-controlled, mixed-model design, 22 individuals completed various cognitive tasks and self-report questionnaires over 36 hours of continuous wakefulness. Results demonstrated that performance of fatigue-vulnerable individuals was significantly improved by modafinil administration fatigue-resistant individuals did not receive a similar boost. The improvements were task dependent, with some tasks showing marked effects while others showing little to no effects. Subjective assessments demonstrated that modafinil did not affect fatigue-vulnerable individuals differently from fatigue-resistant individuals. Pursuing differentiation of those who benefit most from modafinil allows for more precise resource allocation by tailoring fatigue-countermeasures by need. Improvements in performance for fatigue-vulnerable individuals equates to fewer errors in tactical settings and improved wartime outcomes.
Descriptive Note:
Technical Report,01 Sep 2016,31 Aug 2020
Pages:
0152
Distribution Statement:
Approved For Public Release;
File Size:
8.19MB
