Accession Number:

AD1099742

Title:

Soman-Induced Status Epilepticus, Epileptogenesis, and Neuropathology in Carboxylesterase Knockout Mice Treated with Midazolam

Personal Author(s):

Corporate Author:

ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD ABERDEEN PROVING GROUND United States

Report Date:

2018-10-25

Abstract:

Carboxylesterase knockout ES1 mice are more susceptible than wild-type C57BL6 mice to the lethal effects of soman. Spontaneous recurrent seizures develop in ES1 mice following soman-induced status epilepticus when midazolam treatment is delayed. Severe neuronal loss and neuroinflammation are present in ES1 mice 2 weeks following soman-induced status epilepticus. ES1 mice show acute and subchronic electroencephalography EEG power spectra changes after soman-induced status epilepticus and midazolam treatment is delayed.

Descriptive Note:

Journal Article - Open Access

Supplementary Note:

Epilepsia , 59, 1-13, 01 Jan 0001, 01 Jan 0001,

Pages:

0014

Descriptors:

Identifiers:

Subject Categories:

Communities Of Interest:

Modernization Areas:

Distribution Statement:

Approved For Public Release;

File Size:

2.32MB

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