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Human Cell Line Activation Test of the Novel Energetic N,N'- bis(4 nitro 1,2,5 oxadiazol 3 yl)-methanediamine (MBANF)

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Army Public Health Center Aberdeen Proving Ground United States

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The energetic and toxicological properties of n,n-bis4-nitro-1,2,5-oxadiazol-3-yl-methanediamine MBANF are under assessment as replacements for energetics in current use, such as such as hexahydro-1,3,5-trinitro-1,3,5-triazine RD and trinitrotoluene TNT. This study evaluated the skin sensitization hazard of MBANF through the h-CLAT, an in vitro approach to assess activation of dendritic cells. Data from the h-CLAT were also utilized to predict a Hazard Category UNECE2015 for acute oral toxicity. Data from this study are used to assist in making environment and health-based decisions regarding the design and selection of formulas and materials for development of new munition compounds.

Descriptive Note:

Technical Report,01 Feb 2020,31 Mar 2020



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Approved For Public Release;

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