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Accession Number:
AD1098687
Title:
Integrin Regulation of Ferroptosis in Breast Cancer
Corporate Author:
University of Massachusetts Medical School Worcester United States
Report Date:
2019-11-01
Abstract:
The hypothesis being tested in this proposal is that breast cancer cells, especially metastatic cells, are prone to rapid increases in ROS and lipid peroxidation caused by adverse micro-environmental conditions and that these oxidative bursts could have deleterious consequences including ferroptosis. Ferroptosis is defined as an iron-dependent, non-apoptotic form of programmed cell death characterized by the accumulation of intracellular soluble and lipid reactive oxygen species ROS.For this reason, breast tumor cells must acquire mechanisms to protect against oxidative bursts and ferroptosis to metastasize.
Descriptive Note:
Technical Report,15 Jan 2017,14 Jul 2019
Pages:
0044
Distribution Statement:
Approved For Public Release;
File Size:
9.73MB
