DID YOU KNOW? DTIC has over 3.5 million final reports on DoD funded research, development, test, and evaluation activities available to our registered users. Click
HERE to register or log in.
Accession Number:
AD1096238
Title:
Reinnervation of Paralyzed Muscle by Nerve-Muscle-Endplate Band Grafting
Corporate Author:
Hackensack University Medical Center Hackensack United States
Report Date:
2018-12-01
Abstract:
This research aimed to assess the efficacy of our recently developed a new surgical technique called nerve-muscle-endplate grafting NMEG in the native motor zone NMZ for muscle reinnervation in a rat neck muscle model. An NMEG harvested from a donor muscle was implanted into the NMZ of the experimentally denervated muscle. Our experiments showed that NMEG-NMZ technique yielded optimal functional recovery 82 of the control of the target muscle. Importantly, the outcome of the NMEG-NMZ was further improved by additional use of exogenous neurotrophic factors ENF and intraoperative brief electrical stimulation ES. Specifically, the combination of NMEG-NMZ with ENF and ES resulted in more optimal functional recovery 91 and 90 of the control, respectively as compared with NMEG-NMZ surgery alone. Our studies have demonstrated that NMEG-NMZ procedure physically facilitates rapid axon-endplate connections and that focal administration of the ENF and intraoperative brief ES result in extensive nerve regeneration and muscle reinnervation.
Descriptive Note:
Technical Report,15 Sep 2014,14 Sep 2018
Pages:
0099
Distribution Statement:
Approved For Public Release;
File Size:
11.84MB
